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Beilstein J. Org. Chem. 2012, 8, 1804–1813, doi:10.3762/bjoc.8.206
Graphical Abstract
Scheme 1: Three-step sequence for the preparation of γ-lactams from maleimides, aldehydes and amines. Potenti...
Scheme 2: The transfer of the diastereoselective ratio of 3 to the enantioselectivity of the overall process ...
Scheme 3: Combination of the Michael addition step with the reductive amination/lactamization step and of the...
Scheme 4: Combination of the Michael addition, the reductive amination/lactamization, and the epimerization s...
Scheme 5: Chemspeed 4 × 8 × 8 library of γ-lactams 6.